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L-arginine and the risk factor ADMA

L-Arginine has a vasodilating effect, unlike its opponent ADMA. ADMA has therefore been considered a cardiovascular risk factor since 2003 and is therefore involved in the development of various diseases such as arteriosclerosis . You can find out exactly what ADMA is and how arginine supplementation can help with high plasma levels in our new blog post.


  1. L-Arginine leads to the formation of nitric oxide
  2. What is ADMA?
  3. Diseases with frequently elevated ADMA concentrations
  4. Nutri-Plus L-Arginine Base Powder

L-Arginine leads to the formation of nitric oxide

Arginine has a total of four nitrogen groups, making it the most nitrogen-rich amino acid in the human body. In a healthy person, sufficient nitric oxide (NO) is formed in the blood vessel wall from L-arginine . Nitric oxide is a protective molecule to dilate the blood vessels. If too little nitric oxide is formed, disorders can occur in the cell layer of the blood vessels and diseases such as arteriosclerosis can be favoured.

What is ADMA?

ADMA stands for Asymmetric Dimethylarginine and is a methylated derivative of the amino acid L-arginine. This endogenous substance is found in the blood plasma. In a healthy person, the normal value in the blood is 0.7 micromoles per litre. ADMA is produced as a degradation product of the constant protein metabolism throughout the body. Normally, the majority of the ADMA formed is broken down quickly. This keeps the concentration within limits. In certain diseases , however, up to 4-fold higher plasma levels are recorded. However, the exact mechanism behind the increase in ADMA in the blood is not yet known.

ADMA prevents the protective function of L-arginine by inhibiting nitric oxide synthesis in the body. If the ADMA level in the blood is also high, no nitric oxide is formed. It therefore represents a decisive disease factor. Various studies therefore show that a high level is associated with an increased risk of cardiovascular disease.

Diseases with frequently elevated ADMA concentrations:

  • Hypertension
  • Diabetes mellitus
  • Elevated cholesterol levels
  • Lipid metabolism disorders
  • Cardiovascular diseases (e. g. B. Circulatory disorders)
  • Chronic kidney disease

    People with high ADMA plasma levels therefore benefit from supplementation with L-arginine or also L-Citrulline, as this restarts the production of nitric oxide. It is therefore advisable to have the ADMA levels in the blood checked in the event of cardiovascular disease or other illnesses. Studies also show that the use of L-arginine supplements in particular in the early phase of arteriosclerosis seems to make sense, as it can reduce functional disorders.

Nutri-Plus L-Arginine Base Powder

Our L-arginine in powder form is highly dosed and has a higher bioavailability than commonly used arginine HCL. Our powder can also be mixed with other food supplements such as citrulline or our protein powder. Due to the powder form, a free dosage is possible. L-arginine is also well tolerated in very high concentrations (20 g per day). In contrast, only occasional symptoms such as diarrhoea, nausea or headaches occur. We therefore recommend taking 5 g of powder daily.